Immune dyscrasia in adult growth hormone deficiency: Evaluation of hemolytic complement activity (CH50) and IgG subclasses
نویسندگان
چکیده
منابع مشابه
Adult Growth Hormone Deficiency
Adult growth hormone deficiency (AGHD) is an heterogeneous clinical entity characterized by increased cardiovascular morbidity and mortality, alterations in body composition, osteoporosis and impaired quality of life. In order to characterize higher risk subpopulations we studied 77 patients with AGHD, 35 with childhood onset (AGHD-CO): CA 18-44 yr.; 13 females and 22 males, and 42 with adult o...
متن کاملAdult growth hormone deficiency.
Growth hormone (GH) has an important physiological role in adulthood.1–3 Before the 1980s anecdotal reports suggested that patients lacking GH experienced symptoms of increased fatigue and low mood, features that improved with GH replacement.4 Long-term replacement was not considered because of the lack of availability of cadaveric GH. With the development of recombinant GH in the mid-1980s, in...
متن کاملMeasuring the 50% haemolytic complement (CH50) activity of serum.
The complement system is a group of proteins that when activated lead to target cell lysis and facilitates phagocytosis through opsonisation. Individual complement components can be quantified however this does not provide any information as to the activity of the pathway. The CH50 is a screening assay for the activation of the classical complement pathway (Fig 1) and it is sensitive to the red...
متن کاملAdult Growth Hormone Deficiency: Current Concepts
The clinical syndrome of adult growth hormone deficiency (AGHD) was widely recognized in the 1980s. In this review, we first describe the clinical features and diagnosis of AGHD and then state the effects of growth hormone (GH) therapy for these patients. The main characteristics of AGHD are abnormal body composition, dyslipidemia, insulin resistance, and an impaired quality of life (QoL) due t...
متن کاملParathyroid responsiveness to hypocalcemic and hypercalcemic stimuli in adult growth hormone deficiency after growth hormone replacement.
Adult growth hormone deficiency (AGHD) is associated with osteoporosis. Previous reports have suggested that alterations in parathyroid gland responsiveness to changes in calcium concentration may play a role in the genesis of osteoporosis in untreated AGHD patients. We investigated the endogenous parathyroid hormone [PTH-(1-84)] response to hypocalcemic and hypercalcemic stimuli induced by sod...
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ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2020
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2020.110757